Безопасно. Совместимый. Минимальный риск для грудного вскармливания и ребёнка.
Антидепрессант СИОЗС со свойствами и применением, подобными флуоксетину. Пероральное введение однократной суточной дозы.
Он выделяется с грудным молоком в неопределяемом или клинически незначительном количестве.(Schoretsanitis 2019, Pogliani 2019, Weisskopf 2017, Salazar 2016, Weissman 2004, Berle 2004, Stowe 2003 and 1997, Hendrick 2001, Dodd 2000, Kristensen 1998, Altshuler 1995)
Уровни в плазме у младенцев, матери которых принимают сертралин, обычно очень низкие или ниже предела обнаружения. (Wisner 2006, Stowe 2003 and 1997, Hendrick 2001, Dodd 2001, Epperson 2001 and 1997, Wisner 1998, Kristensen 1998, Mammen 1997, Altshuler 1995)
Никаких краткосрочных или долгосрочных клинических последствий или последствий для развития не наблюдалось. (Pogliani 2019, Stowe 2003 and 1997, Hendrick 2003 and 2001, Kristensen 1998, Mammen 1997, Altshuler 1995)
В раннем неонатальном периоде могут возникнуть преходящие проблемы, такие как синдром отмены антидепрессантов или гиперстимуляция серотонина, у доношенных или недоношенных детей, рожденных с высокими уровнями в плазме, поскольку их матери принимали сертралин во время беременности. (Müller 2013, Hale 2010)
Хотя сертралин реже, чем другие антидепрессанты, он может вызывать галакторею (Nebhinani 2013, Lesaca 1996) с (Petit 2003) или без (Trenque 2011, Sagud 2002, Gordon 1998) гиперпролактинемии. Также может быть временное снижение выработки молока, которое улучшается при хорошей гидратации. (Holland 2000)
Это, пожалуй, самый безопасный антидепрессант при грудном вскармливании.
Различные медицинские общества и консенсус экспертов считают использование этого лекарства безопасным во время грудного вскармливания. (Hale, LactMed, Uguz 2021, Molenaar 2018, Mcallister 2017, Pinheiro 2015, Sriraman 2015, Orsolini 2015, Davanzo 2014 and 2011, Rowe 2013, Berle 2011 , Patil 2011, Amir 2011, Lanza 2009, ABM 2008, Gentile 2005, Weissman 2004, Rubin 2004, Gjerdingen 2003, Wisner 2002 and 1996, Nordeng 2001)
Женщины, страдающие депрессией во время беременности, нуждаются в большей поддержке грудного вскармливания из-за повышенного риска проблем и раннего прекращения грудного вскармливания. (Grzeskowiak 2018, Leggett 2017, Venkatesh 2017, Gorman 2012)
| Наименование | Значение | Ед.изм. |
|---|---|---|
| Tmax | 4.5 - 8.4 | час |
| T½ | 24 - 26 | час |
| БПП | 100 | % |
| Молекулярная масса | 343 | Да |
| ОР | 20 | л/кг |
| Относительная доза | 0.003 | % |
| Связывание с белками | 98 | % |
| Соотношение М/П | 0.9 | - |
| Теоретическая доза | 0.00002 | мг/кг/сут |
См. ниже информацию об этих сопутствующих препаратах:
Депрессия у кормящей матери ◐ Умеренный риск
Альтернатив: не найдено
Автор: Mammen OK, Perel JM, Rudolph G, Foglia JP, Wheeler SB.
Sertraline and norsertraline levels in three breastfed infants.
J Clin Psychiatry.
Автор: Wisner KL, Perel JM, Findling RL.
Antidepressant treatment during breast-feeding.
Am J Psychiatry. 1996 Sep;153(9):1132-7. Review.
Автор: Altshuler LL, Burt VK, McMullen M, Hendrick V.
Breastfeeding and sertraline: a 24-hour analysis.
J Clin Psychiatry.
Автор: Epperson CN, Anderson GM, McDougle CJ.
Sertraline and breast-feeding.
N Engl J Med.
Автор: Stowe ZN, Owens MJ, Landry JC, Kilts CD, Ely T, Llewellyn A, Nemeroff CB.
Sertraline and desmethylsertraline in human breast milk and nursing infants.
Am J Psychiatry.
Автор: Gordon C, Whale R, Cowen PJ.
Sertraline treatment does not increase plasma prolactin levels in healthy subjects.
Psychopharmacology (Berl).
Автор: Wisner KL, Perel JM, Blumer J.
Serum sertraline and N-desmethylsertraline levels in breast-feeding mother-infant pairs.
Am J Psychiatry.
Автор: Dodd S, Stocky A, Buist A, Burrows GD, Maguire K, Norman TR.
Sertraline in paired blood plasma and breast-milk samples from nursing mothers.
Hum Psychopharmacol.
Автор: Holland D.
An observation of the effect of sertraline on breast milk supply.
Aust N Z J Psychiatry.
Автор: Kristensen JH, Ilett KF, Dusci LJ, Hackett LP, Yapp P, Wojnar-Horton RE, Roberts MJ, Paech M.
Distribution and excretion of sertraline and N-desmethylsertraline in human milk.
Br J Clin Pharmacol.
Автор: Larsen ER, Damkier P, Pedersen LH, Fenger-Gron J, Mikkelsen RL, Nielsen RE, Linde VJ, Knudsen HE, Skaarup L, Videbech P.
Use of psychotropic drugs during pregnancy and breast-feeding.
Acta Psychiatr Scand Suppl.
Автор: Sriraman NK, Melvin K, Meltzer-Brody S.
ABM Clinical Protocol #18: Use of Antidepressants in Breastfeeding Mothers.
Breastfeed Med.
Автор: Orsolini L, Bellantuono C.
Serotonin reuptake inhibitors and breastfeeding: a systematic review.
Hum Psychopharmacol. 2015 Jan;30(1):4-20.
Автор: Davanzo R, Bua J, Paloni G, Facchina G.
Breastfeeding and migraine drugs.
Eur J Clin Pharmacol.
Автор: Rowe H, Baker T, Hale TW.
Maternal medication, drug use, and breastfeeding.
Pediatr Clin North Am. 2013 Feb;60(1):275-94.
Автор: Nebhinani N.
Sertraline-induced galactorrhea: case report and review of cases reported with other SSRIs.
Gen Hosp Psychiatry.
Автор: Müller MJ, Preuß C, Paul T, Streit F, Brandhorst G, Seeliger S.
Serotonergic overstimulation in a preterm infant after sertraline intake via breastmilk.
Breastfeed Med.
Автор: Gorman JR, Kao K, Chambers CD.
Breastfeeding among women exposed to antidepressants during pregnancy.
J Hum Lact.
Автор: Trenque T, Herlem E, Auriche P, Dramé M.
Serotonin reuptake inhibitors and hyperprolactinaemia: a case/non-case study in the French pharmacovigilance database.
Drug Saf.
Автор: Amir LH, Pirotta MV, Raval M.
Breastfeeding--evidence based guidelines for the use of medicines.
Aust Fam Physician. 2011 Sep;40(9):684-90. Review.
Автор: Berle JO, Spigset O.
Antidepressant Use During Breastfeeding.
Curr Womens Health Rev.
Автор: Davanzo R, Copertino M, De Cunto A, Minen F, Amaddeo A.
Antidepressant drugs and breastfeeding: a review of the literature.
Breastfeed Med.
Автор: Patil AS, Kuller JA, Rhee EH.
Antidepressants in pregnancy: a review of commonly prescribed medications.
Obstet Gynecol Surv.
Автор: Hale TW, Kendall-Tackett K, Cong Z, Votta R, McCurdy F.
Discontinuation syndrome in newborns whose mothers took antidepressants while pregnant or breastfeeding.
Breastfeed Med.
Автор: Lanza di Scalea T, Wisner KL.
Antidepressant medication use during breastfeeding.
Clin Obstet Gynecol.
Автор: Academy of Breastfeeding Medicine Protocol Committee.
ABM clinical protocol #18: use of antidepressants in nursing mothers.
Breastfeed Med.
Автор: Wisner KL, Hanusa BH, Perel JM, Peindl KS, Piontek CM, Sit DK, Findling RL, Moses-Kolko EL.
Postpartum depression: a randomized trial of sertraline versus nortriptyline.
J Clin Psychopharmacol.
Автор: Gentile S.
The safety of newer antidepressants in pregnancy and breastfeeding.
Drug Saf.
Автор: Rubin ET, Lee A, Ito S.
When breastfeeding mothers need CNS-acting drugs.
Can J Clin Pharmacol. 2004 Fall;11(2):e257-66. Epub 2004 Dec 8.
Автор: Berle JØ, Steen VM, Aamo TO, Breilid H, Zahlsen K, Spigset O.
Breastfeeding during maternal antidepressant treatment with serotonin reuptake inhibitors: infant exposure, clinical symptoms, and cytochrome p450 genotypes.
J Clin Psychiatry.
Автор: Weissman AM, Levy BT, Hartz AJ, Bentler S, Donohue M, Ellingrod VL, Wisner KL.
Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infants.
Am J Psychiatry.
Автор: Gjerdingen D.
The effectiveness of various postpartum depression treatments and the impact of antidepressant drugs on nursing infants.
J Am Board Fam Pract.
Автор: Hendrick V, Smith LM, Hwang S, Altshuler LL, Haynes D.
Weight gain in breastfed infants of mothers taking antidepressant medications.
J Clin Psychiatry.
Автор: Stowe ZN, Hostetter AL, Owens MJ, Ritchie JC, Sternberg K, Cohen LS, Nemeroff CB.
The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations.
J Clin Psychiatry.
Автор: Petit A, Piednoir D, Germain ML, Trenque T.
[Drug-induced hyperprolactinemia: a case-non-case study from the national pharmacovigilance database].
Therapie.
Автор: Sagud M, Pivac N, Mück-Seler D, Jakovljevi? M, Mihaljevi?-Peles A, Korsi? M.
Effects of sertraline treatment on plasma cortisol, prolactin and thyroid hormones in female depressed patients.
Neuropsychobiology.
Автор: Wisner KL, Parry BL, Piontek CM.
Clinical practice. Postpartum depression.
N Engl J Med.
Автор: DeVane CL, Liston HL, Markowitz JS.
Clinical pharmacokinetics of sertraline.
Clin Pharmacokinet.
Автор: Nordeng H, Bergsholm YK, Bøhler E, Spigset O.
Overgang av selektive serotoninreopptakshemmere til morsmelk \ [The transfer of selective serotonin reuptake inhibitors to human milk].
Tidsskr Nor Laegeforen.
Автор: Dodd S, Stocky A, Buist A, Burrows GD, Norman TR.
Sertraline analysis in the plasma of breast-fed infants.
Aust N Z J Psychiatry.
Автор: Hendrick V, Fukuchi A, Altshuler L, Widawski M, Wertheimer A, Brunhuber MV.
Use of sertraline, paroxetine and fluvoxamine by nursing women.
Br J Psychiatry.
Автор: Epperson N, Czarkowski KA, Ward-O'Brien D, Weiss E, Gueorguieva R, Jatlow P, Anderson GM.
Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs.
Am J Psychiatry.
Автор: LactMed.
Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/
2006 -
Автор: Hale TW.
Medications & Mothers' Milk.
1991- . Springer Publishing Company. Available from https://www.halesmeds.com
Автор: Uguz F.
A New Safety Scoring System for the Use of Psychotropic Drugs During Lactation.
Am J Ther. 2021 Jan-Feb 01;28(1):e118-e126.
Автор: Pogliani L, Baldelli S, Cattaneo D, Pileri P, Clementi E, Cetin I, Zuccotti G.
Selective serotonin reuptake inhibitors' passage into human milk of lactating women.
J Matern Fetal Neonatal Med. 2019 Sep;32(18):3020-3025.
Автор: Schoretsanitis G, Augustin M, Saßmannshausen H, Franz C, Gründer G, Paulzen M.
Antidepressants in breast milk; comparative analysis of excretion ratios.
Arch Womens Ment Health. 2019 Jun;22(3):383-390.
Автор: Rybakowski J, Cuba?a WJ, Ga?ecki P, Rymaszewska J, Samochowiec J, Szulc A, Dudek D.
Recommendations of the Polish Psychiatric Association regarding the treatment of affective disorders in women of childbearing age. Part II: Bipolar disorder.
Psychiatr Pol. 2019 Apr 30;53(2):263-276.
Автор: Molenaar NM, Kamperman AM, Boyce P, Bergink V.
Guidelines on treatment of perinatal depression with antidepressants: An international review.
Aust N Z J Psychiatry. 2018 Apr;52(4):320-327.
Автор: Grzeskowiak LE, Leggett C, Costi L, Roberts CT, Amir LH.
Impact of serotonin reuptake inhibitor use on breast milk supply in mothers of preterm infants: a retrospective cohort study.
Br J Clin Pharmacol. 2018 Jun;84(6):1373-1379.
Автор: Leggett C, Costi L, Morrison JL, Clifton VL, Grzeskowiak LE.
Antidepressant Use in Late Gestation and Breastfeeding Rates at Discharge from Hospital.
J Hum Lact. 2017 Nov;33(4):701-709.
Автор: Venkatesh KK, Castro VM, Perlis RH, Kaimal AJ.
Impact of antidepressant treatment during pregnancy on obstetric outcomes among women previously treated for depression: an observational cohort study.
J Perinatol. 2017 Sep;37(9):1003-1009.
Автор: Weisskopf E, Panchaud A, Nguyen KA, Grosjean D, Hascoët JM, Csajka C, Eap CB, Ansermot N; collaborators of the SSRI-Breast Milk study..
Simultaneous determination of selective serotonin reuptake inhibitors and their main metabolites in human breast milk by liquid chromatography-electrospray mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jul 1;1057:101-109.
Автор: McAllister-Williams RH, Baldwin DS, Cantwell R, Easter A, Gilvarry E, Glover V, Green L, Gregoire A, Howard LM, Jones I, Khalifeh H, Lingford-Hughes A, McDonald E, Micali N, Pariante CM, Peters L, Roberts A, Smith NC, Taylor D, Wieck A, Yates LM, Young AH; et al.
British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017.
J Psychopharmacol. 2017 May;31(5):519-552.
Автор: Salazar FR, D'Avila FB, de Oliveira MH, Ferreira PL, Bergold AM.
Development and validation of a bioanalytical method for five antidepressants in human milk by LC-MS.
J Pharm Biomed Anal. 2016 Sep 10;129:502-508.
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