Безопасно. Совместимый. Минимальный риск для грудного вскармливания и ребёнка.
Антидепрессант SSRI с действиями и использует аналогично таковым у флуоксетина.
Одное введение один раз в день.
Он выводится в грудном молоке в клинически незначительных количествах (Pogliani 2019, Weisskopf 2017, Salazar 2016, Misri 2006 Y 2000, Stowe 2000, Ohman 1999, Begg 1999, Spigset 1996). Уровни в сыворотке у младенцев на грудном вскармливании, чьи матери находятся на пароксетине, обычно не обнаруживаются или очень низкие (Berle 2004, Hendrick 2001, Misri 2000, Begg 1999, Birnbaum 1999). НЕТ НАХОДЕНИЯ НЕ НЕИЗВЕСТНО о ЗДОРОВЬЕ И КРАТКОЕ ИЛИ ДОЛНОСТЬ ДОЛЖНОСТИ ДЕТАТЬ Младенцев (Pogliani 2019, Uguz 2019 Y 2016, Berle 2004, Merlob 2004, Hendrick 2003, Ohman 1999, Begg 1999).
Проблемы с преходящими в раннем периоде новорожденных, такие как синдром отмены лекарств среди новорожденных или недоношенных детей с высоким уровнем сыворотки в результате лечения пароксетина к матери во время беременности (Hale 2010, Knoppert 2006, Costei 2002, Stiskal 2001 , Nordeng 2001).
пароксетин, как и другие антидепрессанты, может вызвать галакторею проблемы с или без гиперпролактинемии (Mishra 2019, Kumar 2018, Trenque 2011, Chakraborty 2010, Davenport 2002, Morrison 2001, González 2000, Bonin 1997, Egberts 1997).
Несколько медицинских обществ, экспертов и консенсуса экспертов, рассмотрим использование этого лекарства безопасным или, вероятно, безопасным во время грудного вскармливания (Hale, Lactmed, Salazar 2016, Uguz 2021, 2019 Y 2016, Orsolini 2015, Sriraman 2015, Rowe 2013, Amir 2011 , Berle 2011, Patil 2011, Lanza 2009, ABM 2008, Field 2008, Gentile 2005, Weissman 2004, Rubin 2004, Gjerdingen 2003, Wisner 2002, Nordeng 2001).
Женщины, страдающие депрессией во время беременности, нуждаются в большей поддержке грудного вскармливания из -за повышенного риска проблем с грудным вскармливанием и раннего отлучения (Grzeskowiak 2018, Leggett 2017, Gorman 2012).
| Наименование | Значение | Ед.изм. |
|---|---|---|
| pKa | 9.8 | моль/л |
| Tmax | 6 - 10 | час |
| T½ | 15 - 33 | час |
| БПП | 100 | % |
| Молекулярная масса | 366 | Да |
| ОР | > 1 | л/кг |
| Относительная доза | 2 - 5 | % |
| Связывание с белками | 93 - 95 | % |
| Соотношение М/П | 0.06 - 1.3 | - |
| Теоретическая доза | 0.02 | мг/кг/сут |
См. ниже информацию об этих сопутствующих препаратах:
Депрессия у кормящей матери ◐ Умеренный риск
Автор: Ohman R, Hägg S, Carleborg L, Spigset O.
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Paroxetine and galactorrhea.
Pharmacopsychiatry.
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Non-puerperal lactation associated with antidepressant drug use.
Br J Clin Pharmacol.
Автор: Spigset O, Carleborg L, Norström A, Sandlund M.
Paroxetine level in breast milk.
J Clin Psychiatry.
Автор: Misri S, Kim J, Riggs KW, Kostaras X.
Paroxetine levels in postpartum depressed women, breast milk, and infant serum.
J Clin Psychiatry.
Автор: González E, Minguez L, Sanguino RM.
Galactorrhea after paroxetine treatment.
Pharmacopsychiatry.
Автор: Hendrick V, Stowe ZN, Altshuler LL, Hostetter A, Fukuchi A.
Paroxetine use during breast-feeding.
J Clin Psychopharmacol.
Автор: Birnbaum CS, Cohen LS, Bailey JW, Grush LR, Robertson LM, Stowe ZN.
Serum concentrations of antidepressants and benzodiazepines in nursing infants: A case series.
Pediatrics.
Автор: Begg EJ, Duffull SB, Saunders DA, Buttimore RC, Ilett KF, Hackett LP, Yapp P, Wilson DA.
Paroxetine in human milk.
Br J Clin Pharmacol.
Автор: Wisner KL, Parry BL, Piontek CM.
Clinical practice. Postpartum depression.
N Engl J Med.
Автор: Davenport E, Velamoor R.
A case of paroxetine-induced galactorrhea.
Can J Psychiatry.
Автор: Wisner KL, Findling RL, Perel JM.
Paroxetine in breast milk.
Am J Psychiatry.
Автор: Nordeng H, Lindemann R, Perminov KV, Reikvam A.
Neonatal withdrawal syndrome after in utero exposure to selective serotonin reuptake inhibitors.
Acta Paediatr.
Автор: Morrison J, Remick RA, Leung M, Wrixon KJ, Bebb RA.
Galactorrhea induced by paroxetine.
Can J Psychiatry.
Автор: Stiskal JA, Kulin N, Koren G, Ho T, Ito S.
Neonatal paroxetine withdrawal syndrome.
Arch Dis Child Fetal Neonatal Ed. 2001 Mar;84(2):F134-5.
Автор: Hendrick V, Fukuchi A, Altshuler L, Widawski M, Wertheimer A, Brunhuber MV.
Use of sertraline, paroxetine and fluvoxamine by nursing women.
Br J Psychiatry.
Автор: Nordeng H, Bergsholm YK, Bøhler E, Spigset O.
Overgang av selektive serotoninreopptakshemmere til morsmelk \ [The transfer of selective serotonin reuptake inhibitors to human milk].
Tidsskr Nor Laegeforen.
Автор: Stowe ZN, Cohen LS, Hostetter A, Ritchie JC, Owens MJ, Nemeroff CB.
Paroxetine in human breast milk and nursing infants.
Am J Psychiatry.
Автор: Field T.
Breastfeeding and antidepressants.
Infant Behav Dev. 2008 Sep;31(3):481-7.
Автор: Knoppert DC, Nimkar R, Principi T, Yuen D.
Paroxetine toxicity in a newborn after in utero exposure: clinical symptoms correlate with serum levels.
Ther Drug Monit.
Автор: Misri S, Corral M, Wardrop AA, Kendrick K.
Quetiapine augmentation in lactation: a series of case reports.
J Clin Psychopharmacol. 2006 Oct;26(5):508-11.
Автор: Gentile S.
The safety of newer antidepressants in pregnancy and breastfeeding.
Drug Saf.
Автор: Weissman AM, Levy BT, Hartz AJ, Bentler S, Donohue M, Ellingrod VL, Wisner KL.
Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infants.
Am J Psychiatry.
Автор: Berle JØ, Steen VM, Aamo TO, Breilid H, Zahlsen K, Spigset O.
Breastfeeding during maternal antidepressant treatment with serotonin reuptake inhibitors: infant exposure, clinical symptoms, and cytochrome p450 genotypes.
J Clin Psychiatry.
Автор: Rubin ET, Lee A, Ito S.
When breastfeeding mothers need CNS-acting drugs.
Can J Clin Pharmacol. 2004 Fall;11(2):e257-66. Epub 2004 Dec 8.
Автор: Merlob P, Stahl B, Sulkes J.
Paroxetine during breast-feeding: infant weight gain and maternal adherence to counsel.
Eur J Pediatr.
Автор: Hendrick V, Smith LM, Hwang S, Altshuler LL, Haynes D.
Weight gain in breastfed infants of mothers taking antidepressant medications.
J Clin Psychiatry.
Автор: Gjerdingen D.
The effectiveness of various postpartum depression treatments and the impact of antidepressant drugs on nursing infants.
J Am Board Fam Pract.
Автор: Costei AM, Kozer E, Ho T, Ito S, Koren G.
Perinatal outcome following third trimester exposure to paroxetine.
Arch Pediatr Adolesc Med.
Автор: Hale TW, Kendall-Tackett K, Cong Z, Votta R, McCurdy F.
Discontinuation syndrome in newborns whose mothers took antidepressants while pregnant or breastfeeding.
Breastfeed Med.
Автор: Lanza di Scalea T, Wisner KL.
Antidepressant medication use during breastfeeding.
Clin Obstet Gynecol.
Автор: Academy of Breastfeeding Medicine Protocol Committee.
ABM clinical protocol #18: use of antidepressants in nursing mothers.
Breastfeed Med.
Автор: Weisskopf E, Panchaud A, Nguyen KA, Grosjean D, Hascoët JM, Csajka C, Eap CB, Ansermot N; collaborators of the SSRI-Breast Milk study..
Simultaneous determination of selective serotonin reuptake inhibitors and their main metabolites in human breast milk by liquid chromatography-electrospray mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jul 1;1057:101-109.
Автор: Venkatesh KK, Castro VM, Perlis RH, Kaimal AJ.
Impact of antidepressant treatment during pregnancy on obstetric outcomes among women previously treated for depression: an observational cohort study.
J Perinatol. 2017 Sep;37(9):1003-1009.
Автор: Uguz F, Arpaci N.
Short-Term Safety of Paroxetine and Sertraline in Breastfed Infants: A Retrospective Cohort Study from a University Hospital.
Breastfeed Med. 2016 Nov;11:487-489. Epub 2016 Aug 30.
Автор: Salazar FR, D'Avila FB, de Oliveira MH, Ferreira PL, Bergold AM.
Development and validation of a bioanalytical method for five antidepressants in human milk by LC-MS.
J Pharm Biomed Anal. 2016 Sep 10;129:502-508.
Автор: Sriraman NK, Melvin K, Meltzer-Brody S.
ABM Clinical Protocol #18: Use of Antidepressants in Breastfeeding Mothers.
Breastfeed Med.
Автор: Larsen ER, Damkier P, Pedersen LH, Fenger-Gron J, Mikkelsen RL, Nielsen RE, Linde VJ, Knudsen HE, Skaarup L, Videbech P.
Use of psychotropic drugs during pregnancy and breast-feeding.
Acta Psychiatr Scand Suppl.
Автор: Orsolini L, Bellantuono C.
Serotonin reuptake inhibitors and breastfeeding: a systematic review.
Hum Psychopharmacol. 2015 Jan;30(1):4-20.
Автор: Davanzo R, Bua J, Paloni G, Facchina G.
Breastfeeding and migraine drugs.
Eur J Clin Pharmacol.
Автор: Rowe H, Baker T, Hale TW.
Maternal medication, drug use, and breastfeeding.
Pediatr Clin North Am. 2013 Feb;60(1):275-94.
Автор: Gorman JR, Kao K, Chambers CD.
Breastfeeding among women exposed to antidepressants during pregnancy.
J Hum Lact.
Автор: Amir LH, Pirotta MV, Raval M.
Breastfeeding--evidence based guidelines for the use of medicines.
Aust Fam Physician. 2011 Sep;40(9):684-90. Review.
Автор: Berle JO, Spigset O.
Antidepressant Use During Breastfeeding.
Curr Womens Health Rev.
Автор: Trenque T, Herlem E, Auriche P, Dramé M.
Serotonin reuptake inhibitors and hyperprolactinaemia: a case/non-case study in the French pharmacovigilance database.
Drug Saf.
Автор: Patil AS, Kuller JA, Rhee EH.
Antidepressants in pregnancy: a review of commonly prescribed medications.
Obstet Gynecol Surv.
Автор: Davanzo R, Copertino M, De Cunto A, Minen F, Amaddeo A.
Antidepressant drugs and breastfeeding: a review of the literature.
Breastfeed Med.
Автор: Chakraborty S, Sanyal D, Bhattacharyya R, Dutta S.
A case of paroxetine-induced galactorrhoea with normal serum prolactin level.
Indian J Pharmacol.
Автор: Grzeskowiak LE, Leggett C, Costi L, Roberts CT, Amir LH.
Impact of serotonin reuptake inhibitor use on breast milk supply in mothers of preterm infants: a retrospective cohort study.
Br J Clin Pharmacol. 2018 Jun;84(6):1373-1379.
Автор: Leggett C, Costi L, Morrison JL, Clifton VL, Grzeskowiak LE.
Antidepressant Use in Late Gestation and Breastfeeding Rates at Discharge from Hospital.
J Hum Lact. 2017 Nov;33(4):701-709.
Автор: LactMed.
Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/
2006 -
Автор: Hale TW.
Medications & Mothers' Milk.
1991- . Springer Publishing Company. Available from https://www.halesmeds.com
Автор: Bhattacharjee S, Biswas R, Mandal N.
Selective serotonin reuptake inhibitor-induced galactorrhea with hyperprolactinemia.
Indian J Psychiatry. 2021 Nov-Dec;63(6):613-616.
Автор: Uguz F.
A New Safety Scoring System for the Use of Psychotropic Drugs During Lactation.
Am J Ther. 2021 Jan-Feb 01;28(1):e118-e126.
Автор: Rybakowski J, Cuba?a WJ, Ga?ecki P, Rymaszewska J, Samochowiec J, Szulc A, Dudek D.
Recommendations of the Polish Psychiatric Association regarding the treatment of affective disorders in women of childbearing age. Part II: Bipolar disorder.
Psychiatr Pol. 2019 Apr 30;53(2):263-276.
Автор: Uguz F.
Short-Term Safety of Paroxetine Plus Low-Dose Mirtazapine During Lactation.
Breastfeed Med. 2019 Mar;14(2):131-132.
Автор: Pogliani L, Baldelli S, Cattaneo D, Pileri P, Clementi E, Cetin I, Zuccotti G.
Selective serotonin reuptake inhibitors' passage into human milk of lactating women.
J Matern Fetal Neonatal Med. 2019 Sep;32(18):3020-3025.
Автор: Mishra S, Nath S, Mishra BR, Pattnaik JI.
Euprolactinemic Galactorrhea with Paroxetine: Exploring the Missing Link.
Indian J Psychol Med. 2019 Jul-Aug;41(4):395-397.
Автор: Kumar PNS, Gopalakrishnan A.
Paroxetine induced galactorrhoea - A case report.
Asian J Psychiatr. 2018 Apr;34:31-32.
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