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| Наименование | Значение | Ед.изм. |
|---|---|---|
| pKa | 15.9 | моль/л |
| Tmax | 2.5 | час |
| T½ | 8 (4 - 12) | час |
| БПП | 50 | % |
| Молекулярная масса | 327 | Да |
| ОР | 1.6 | л/кг |
| Относительная доза | 1 - 1.5 | % |
| ПТД | 0.3 - 2 | % |
| Связывание с белками | 97 | % |
| Соотношение М/П | 2.8 - 4.3 | - |
| Теоретическая доза | 0.01 - 0.02 | мг/кг/сут |
Автор: LactMed.
Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/
2006 -
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[Clozapine and agranulocytosis: Rethinking the usefulness of its monitoring].
Aten Primaria. 2021 Oct;53(8):102114.
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A New Safety Scoring System for the Use of Psychotropic Drugs During Lactation.
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The use of clozapine during pregnancy and lactation: A case report.
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Neurodevelopmental and growth follow-up of the baby exposed to antipsychotics during pregnancy and lactation: A case report.
Psychiat Clin Psychopharmacol. 2019;29:744–7. DOI: 10.1080/24750573.2019.1627695
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British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017.
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Автор: Grover S, Avasthi A.
Mood stabilizers in pregnancy and lactation.
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Antipsychotic drugs and safety concerns for breast-feeding infants.
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Antipsychotic drugs and breastfeeding.
Pediatr Endocrinol Rev. 2013 Mar-Apr;10(3):308-17. Review.
Автор: Pons A, Undurraga J, Batalla A, Bernardo M.
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Rev Psiquiatr Salud Ment. 2012 Jan-Mar;5(1):37-42.
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Possible delayed speech acquisition with clozapine therapy during pregnancy and lactation.
J Neuropsychiatry Clin Neurosci. 2007 Spring;19(2):196-7. No abstract available.
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A case of delayed galactorrhoea as an adverse event of overlapping haloperidol and clozapine administration.
Int J Neuropsychopharmacol. 2005 Jun;8(2):303-5. No abstract available.
Автор: Barnas C, Bergant A, Hummer M, Saria A, Fleischhacker WW.
Clozapine concentrations in maternal and fetal plasma, amniotic fluid, and breast milk.
Am J Psychiatry. 1994 Jun;151(6):945. No abstract available.
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