Безопасно. Совместимый. Минимальный риск для грудного вскармливания и ребёнка.
Это производное дибензазепина, обладающее противоэпилептическими и психотропными свойствами. Он используется при лечении некоторых видов эпилепсии, невралгии тройничного нерва, болей при рассеянном склерозе и биполярного расстройства.
В незначительном количестве выделяется с грудным молоком. (Kacirova 2021, Antonucci 2018, Lopes 2012, Zhao 2010, Shimoyama 2000, Brent 1998, Merlob 1992, Meyer 1988, Froescher 1984, Kuhnz 1983, Kok 1982, Niebyl 1979, Kaneko 1979, Pynnönen 1977 y 1975)
У большинства младенцев нет краткосрочных или долгосрочных клинических проблем или проблем развития (Vajda 2014, Meador 2014 и 2010, Veiby 2013, Yogannessen 2005, Wisner 1998, Ito 1993, Niebyl 1979, Pynnönen 1977), хотя единичные случаи сонливости, Сообщалось о плохом питании и преходящей дисфункции печени с холестазом. (Antonucci 2018, Frey 2002, Merlob 1992, Frey 1990, Kuhnz 1983)
Уровни карбамазепина в плазме у младенцев составляли от 5% до 40% от соответствующих уровней у матери и всегда ниже нижнего предела обычного терапевтического диапазона (Mercade 2012: 4–12 мг/л) карбамазепина. (Kacirova 2021, Birnbaum 2020, Antonucci 2018, Grover 2015, Wisner 1998, Merlob 1992, Kuhnz 1983, Kok 1982, Pynnönen 1977 y 1975)
Сообщалось об одном случае синдрома депривации после внезапного прекращения приема препарата. (Knott 1987)
Несколько медицинских обществ и авторы-эксперты считают возможным использование этого препарата во время грудного вскармливания (Hale, LactMed, Uguz 2021, Crettenand 2018, Briggs 2015, Schaefer 2015, Davanzo 2013, Rowe 2013, Mintzer 2011, O'Connor 2009, Harden 2009, Sharma 2009, Even 2006, Pack 2006, Pennell 2006, O'Brien 2005, Bar-Oz 2000, Hägg 2000).
Американская академия педиатрии оценивает его как обычно совместимое с грудным вскармливанием (AAP 2001).
Одиннадцатый типовой список основных лекарственных средств ВОЗ 2002 г.: Совместимы с грудным вскармливанием. (ВОЗ 2002)
| Наименование | Значение | Ед.изм. |
|---|---|---|
| pKa | 15.96 | моль/л |
| Tmax | 6 ± 2 | час |
| T½ | 12 - 17; (1 dosis: | час |
| БПП | 75 - 85 | % |
| Молекулярная масса | 236 | Да |
| ОР | 0.7 - 1.4 | л/кг |
| Относительная доза | 0.8 - 8.3 | % |
| ПТД | 3.75 - 6.75 | % |
| Связывание с белками | 75 - 80 | % |
| Соотношение М/П | 0.2 -0.9 | - |
| Теоретическая доза | 0.1 - 0.7 | мг/кг/сут |
См. ниже информацию об этих сопутствующих препаратах:
Психотические расстройства у матери: психоз, шизофрения, биполярное расстройство ◐ Умеренный риск
Эпилепсия у матери ◐ Умеренный риск
Альтернатив: не найдено
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